About the Talk
Presenter
Gonzalo Parra, PhD: Postdoctoral Researcher, Statistical Genomics and Systems Genetics, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany
Abstract
Advances in single-cell transcriptomics techniques are revolutionizing studies of cellular differentiation and heterogeneity. It has become possible to track the trajectory of thousands of genes across the cellular lineage trees that represent the temporal emergence of cell types during dynamic processes. However, reconstruction of cellular lineage trees with more than a few cell fates has proved challenging.
This talk introduces MERLoT, a tool for reconstructing complex lineage trees from single-cell transcriptomics data, which can also impute temporal gene expression profiles along the reconstructed trees. Its capabilities are demonstrated across real cases and simulated datasets.
Date: February 20th, 2020 – 10:00 (Bogotá)