About the Talk
Presenter
Akdes Serin Harmancı: Center for Computational Systems Medicine, School of Biomedical Informatics, University of Texas Health Science Center at Houston
Abstract
Cancer is a disease of genomic and epigenomic alterations. Single nucleotide changes, copy number variations (CNV), chromosomal rearrangements and modification in DNA methylation together drive the formation of a tumor.
The talk has two parts: the characterisation of non-NF2 meningiomas through integrated genetic and epigenetic analysis, including the mechanisms of atypical meningioma and malignant glioma transformation; and an introduction to CaSpER, an algorithm that identifies, visualises and integrates CNV events at multiscale resolution using single-cell and bulk RNA-sequencing data.
Date: October 23rd, 2018 – 17:30 (Edinburgh)